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We provide an overview of the two most comprehensive current models a 3d model of the omental mesothelium and a microfluidic model. These models will allow us to explore key questions relevant to human cancer immunotherapy and provide a means to screen the impact of immunomodulatory agents e g various adjuvants in the future as we and others develop new cancer immunotherapies. Due to their ability to recapitulate the structural and functional aspect of their matched organs 3d cell culture cancer models have received huge attention from a variety of specialized fields including cell biology molecular biology chemistry physics engineering and nanotechnology this special issue aims to bring together scientists and physicians to discuss the state of the art in in vitro cancer modeling.
Due to their ability to recapitulate the structural and functional aspect of their matched organs 3d cell culture cancer models have received huge attention from a variety of specialized fields including cell biology molecular biology chemistry physics engineering and nanotechnology this special issue aims to bring together scientists and physicians to discuss the state of the art in in vitro cancer modeling.
These models will allow us to explore key questions relevant to human cancer immunotherapy and provide a means to screen the impact of immunomodulatory agents e g various adjuvants in the future as we and others develop new cancer immunotherapies. A major pitfall in translating drugs from the lab bench to a viable treatment is delineating the differences that occur inside a 2d petri dish versus the human body which is inherently 3d. We focus on organotypic 3d models that include at least one type of primary stromal cell type in an ecm background such as collagen or fibronectin plus ovarian cancer cells. Due to their ability to recapitulate the structural and functional aspect of their matched organs 3d cell culture cancer models have received huge attention from a variety of specialized fields including cell biology molecular biology chemistry physics engineering and nanotechnology this special issue aims to bring together scientists and physicians to discuss the state of the art in in vitro cancer modeling.
